Climate change is already adversely affecting population health and health systems, altering the geographic range, seasonality, and incidence of a wide range of climate-sensitive health outcomes, including heat-related illnesses, illnesses caused by poor air quality, undernutrition, and selected vectorborne diseases. Future health risks will be determined by the interaction of the hazards created by a changing climate with the populations and regions exposed to those changes, and the underlying sensitivity and capacity of individuals and populations to prepare for and effectively manage changes in the magnitude and pattern of disease burdens. That is, interactions between climate change and demographic, socioeconomic, and other changes will determine the burden of climate-sensitive health outcomes. Adaptation to prepare for and manage these shifting disease burdens will take place from local to global scales. Climate change is also affecting the functioning of public health and health care systems. Vulnerable populations and regions will be differentially affected, with expected increases in poverty and inequities. Investments and policies to promote proactive and effective adaptation and reductions in greenhouse-gas emissions would decrease the magnitude and pattern of health risks, particularly in the medium-to-long term.